Insertion of a magnesium(II)-octacarboranyl(hexylsulfanyl) porphyrazine into liposomes: a physico-chemical study

Details Insertion of a magnesium(II)-octacarboranyl(hexylsulfanyl) porphyrazine into liposomes: a physico-chemical study Insertion of a magnesium(II)-octacarboranyl(hexylsulfanyl) porphyrazine into liposomes: a physico-chemical study

2007-09-07

arxiv.org/abs/0709.1012v1

Physics

Condensed Matter

Soft Condensed Matter

Scientific paper

The synthesis, characterization and liposome insertion of a novel magnesium(II) carboranyl-porphyrazine, i.e. [2,3,7,8,12,13,17,18-octakis- (1,2-dicarba-closo-dodecaboranyl)-hexylthio-5,10,15,20- porphyrazine]magnesium(II) complex, MgHECSPz, is described. MgHECSPz was designed to improve the potentiality in multiple approach anticancer therapy. Liposomal formulations with different surface charge were prepared as delivering agents. The obtained loaded vectors were characterized by DLS, SAXS, SANS and \zeta potential measurements in order to define the overall properties and structural details of loaded liposomes.

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