Hyperpolarized Long-T1 Silicon Nanoparticles for Magnetic Resonance Imaging

Details Hyperpolarized Long-T1 Silicon Nanoparticles for Magnetic Resonance Imaging Hyperpolarized Long-T1 Silicon Nanoparticles for Magnetic Resonance Imaging

2009-02-02

arxiv.org/abs/0902.0269v1

ACS Nano 3, 4003 (2009)

Physics

Condensed Matter

Materials Science

supporting material here: http://marcuslab.harvard.edu/Aptekar_hyper1_sup.pdf

Scientific paper

10.1021/nn900996p

Silicon nanoparticles are experimentally investigated as a potential hyperpolarized, targetable MRI imaging agent. Nuclear T_1 times at room temperature for a variety of Si nanoparticles are found to be remarkably long (10^2 to 10^4 s) - roughly consistent with predictions of a core-shell diffusion model - allowing them to be transported, administered and imaged on practical time scales without significant loss of polarization. We also report surface functionalization of Si nanoparticles, comparable to approaches used in other biologically targeted nanoparticle systems.

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