Physics – Condensed Matter – Soft Condensed Matter
Scientific paper
2010-06-29
J. Phys. Chem. B 114, 12166-12174 (2010)
Physics
Condensed Matter
Soft Condensed Matter
PDF, 29 pages
Scientific paper
10.1021/jp105912e
Experimental and theoretical analyses of the lactate dehydrogenase and glutathione reductase based enzymatic AND logic gates in which the enzymes and their substrates serve as logic inputs are performed. These two systems are examples of the novel, previously unexplored, class of biochemical logic gates that illustrate potential biomedical applications of biochemical logic. They are characterized by input concentrations at logic 0 and 1 states corresponding to normal and abnormal physiological conditions. Our analysis shows that the logic gates under investigation have similar noise characteristics. Both significantly amplify random noise present in inputs, however we establish that for realistic widths of the input noise distributions, it is still possible to differentiate between the logic 0 and 1 states of the output. This indicates that reliable detection of abnormal biomedical conditions is indeed possible with such enzyme-logic systems.
Bocharova Vera
Chuang Min-Chieh
Halamek Jan
Katz Evgeny
Melnikov Dmitriy
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