A Cooperative Stochastic Model of Gene Expression

Details A Cooperative Stochastic Model of Gene Expression A Cooperative Stochastic Model of Gene Expression

2001-05-11

arxiv.org/abs/cond-mat/0105226v1

Int. J. Mod. Phys. C, 12, 413 (2001)

Physics

Condensed Matter

Soft Condensed Matter

4 pages (Revtex), 3 eps figures (included), to be published in IJMPC

Scientific paper

10.1142/S0129183101001821

Recent experiments at the level of a single cell have shown that gene expression occurs in abrupt stochastic bursts. Further, in an ensemble of cells, the levels of proteins produced have a bimodal distribution. In a large fraction of cells, the gene expression is either off or has a high value. We propose a stochastic model of gene expression the essential features of which are stochasticity and cooperative binding of RNA polymerase. The model can reproduce the bimodal behaviour seen in experiments.

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