Periodically driven stochastic un- and refolding transitions of biopolymers

Details Periodically driven stochastic un- and refolding transitions of biopolymers Periodically driven stochastic un- and refolding transitions of biopolymers

2004-09-23

arxiv.org/abs/cond-mat/0409623v1

Physics

Condensed Matter

Soft Condensed Matter

7 pages, 5 figures, submitted to EPL

Scientific paper

10.1209/epl/i2004-10279-1

Mechanical single molecule experiments probe the energy profile of biomolecules. We show that in the case of a profile with two minima (like folded/unfolded) periodic driving leads to a stochastic resonance-like phenomenon. We demonstrate that the analysis of such data can be used to extract four basic parameters of such a transition and discuss the statistical requirements of the data acquisition. As advantages of the proposed scheme, a polymeric linker is explicitly included and thermal fluctuations within each well need not to be resolved.

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