Two State Behavior in a Solvable Model of $β$-hairpin folding

Details Two State Behavior in a Solvable Model of $β$-hairpin folding Two State Behavior in a Solvable Model of $β$-hairpin folding

1999-08-06

arxiv.org/abs/cond-mat/9908108v2

Physics

Condensed Matter

Soft Condensed Matter

Revised version

Scientific paper

10.1103/PhysRevLett.84.3490

Understanding the mechanism of protein secondary structure formation is an essential part of protein-folding puzzle. Here we describe a simple model for the formation of the $\beta$-hairpin, motivated by the fact that folding of a $\beta$-hairpin captures much of the basic physics of protein folding. We argue that the coupling of ``primary'' backbone stiffness and ``secondary'' contact formation (similar to the coupling between the ``secondary'' and ``tertiary'' structure in globular proteins), caused for example by side-chain packing regularities, is responsible for producing an all-or-none 2-state $\beta$-hairpin formation. We also develop a recursive relation to compute the phase diagram and single exponential folding/unfolding rate arising via a dominant transition state.

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