Physics – Condensed Matter – Statistical Mechanics
Scientific paper
2002-07-01
Physics
Condensed Matter
Statistical Mechanics
Scientific paper
Two processes can influence the evolution of protein interaction networks: addition and elimination of interactions between proteins, and gene duplications increasing the number of proteins and interactions. The rates of these processes can be estimated from available Saccharomyces cerevisiae genome data and are sufficiently high to affect network structure on short time scales. For instance, more than 100 interactions may be added to the yeast network every million years, a substantial fraction of which adds previously unconnected proteins to the network. Highly connected proteins show a greater rate of interaction turnover than proteins with few interactions. From these observations one can explain ? without natural selection on global network structure ? the evolutionary sustenance of the most prominent network feature, the distribution of the frequency P(d) of proteins with d neighbors, which is a broad-tailed distribution. This distribution is independent of the experimental approach providing nformation on network structure.
No associations
LandOfFree
How the global structure of protein interaction networks evolves does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with How the global structure of protein interaction networks evolves, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and How the global structure of protein interaction networks evolves will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-632265