Single Stranded DNA Translocation Through A Nanopore: A Master Equation Approach

Details Single Stranded DNA Translocation Through A Nanopore: A Master Equation Approach Single Stranded DNA Translocation Through A Nanopore: A Master Equation Approach

2003-07-02

arxiv.org/abs/cond-mat/0307060v2

Phys. Rev. E 68, 041910 (2003)

Physics

Condensed Matter

Statistical Mechanics

7 pages submitted to PRE

Scientific paper

10.1103/PhysRevE.68.041910

We study voltage driven translocation of a single stranded (ss) DNA through a membrane channel. Our model, based on a master equation (ME) approach, investigates the probability density function (pdf) of the translocation times, and shows that it can be either double or mono-peaked, depending on the system parameters. We show that the most probable translocation time is proportional to the polymer length, and inversely proportional to the first or second power of the voltage, depending on the initial conditions. The model recovers experimental observations on hetro-polymers when using their properties inside the pore, such as stiffness and polymer-pore interaction.

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