Physics – Condensed Matter – Statistical Mechanics
Scientific paper
2008-06-28
Phy. Rev. E 78, 021905 (2008)
Physics
Condensed Matter
Statistical Mechanics
8 pages, 11 figures
Scientific paper
10.1103/PhysRevE.78.021905
Single molecule force spectroscopy provide details of the underlying energy surfaces of proteins which are essential to the understanding of their unfolding process. Recently, it has been observed experimentally that by pulling proteins in different directions relative to their secondary structure, one can gain a better understanding of the shape of the energy landscape. We consider simple lattice models which are anisotropic in nature to study the response of a force in unfolding of a polymer. Our analytical solution of the model, supported by extensive numerical calculations, reveal that the force temperature diagrams are very different depending on the direction of the applied force. We find that either unzipping or shearing kind transitions dominate the dynamics of the unfolding process depending solely on the direction of the applied force.
Giri Debaprasad
Jensen Iwan
Kumar Sanjeev
Rajesh R.
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