DNA sequence from the unzipping force? : one mutation problem

Details DNA sequence from the unzipping force? : one mutation problem DNA sequence from the unzipping force? : one mutation problem

2001-06-06

arxiv.org/abs/cond-mat/0106110v2

J. Phys. A 35, L349 (2002)

Physics

Condensed Matter

Statistical Mechanics

11 pages, 4 figures. Revised version with minor changes. Paragraph with discussion on experiments added. Accepted for publicat

Scientific paper

10.1088/0305-4470/35/26/101

The possibility of detecting mutations in a DNA from force measurements (as a first step towards sequence analysis) is discussed theoretically based on exact calculations. The force signal is associated with the domain wall separating the zipped from the unzipped regions. We propose a comparison method (``differential force microscope'') to detect mutations. Two lattice models are treated as specific examples.

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