Physics – Condensed Matter – Disordered Systems and Neural Networks
Scientific paper
2003-04-09
Eur. Phys. J. B 41, 113-121 (2004)
Physics
Condensed Matter
Disordered Systems and Neural Networks
19 pages, 9 figures, 1 table, to appear in Euro. Phys. J. B
Scientific paper
10.1140/epjb/e2004-00301-0
The budding yeast {\it Saccharomyces cerevisiae} is the first eukaryote whose genome has been completely sequenced. It is also the first eukaryotic cell whose proteome (the set of all proteins) and interactome (the network of all mutual interactions between proteins) has been analyzed. In this paper we study the structure of the yeast protein complex network in which weighted edges between complexes represent the number of shared proteins. It is found that the network of protein complexes is a small world network with scale free behavior for many of its distributions. However we find that there are no strong correlations between the weights and degrees of neighboring complexes. To reveal non-random features of the network we also compare it with a null model in which the complexes randomly select their proteins. Finally we propose a simple evolutionary model based on duplication and divergence of proteins.
Karimipour Vahid
Mashaghi A. R.
Ramezanpour Abolfazl
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