Theory of Bubble Nucleation and Cooperativity in DNA Melting

Details Theory of Bubble Nucleation and Cooperativity in DNA Melting Theory of Bubble Nucleation and Cooperativity in DNA Melting

2004-12-21

arxiv.org/abs/cond-mat/0412591v1

Physics

Condensed Matter

Statistical Mechanics

4 figures. Accepted for publication in Physical Review Letters

Scientific paper

10.1103/PhysRevLett.94.035504

The onset of intermediate states (denaturation bubbles) and their role during the melting transition of DNA are studied using the Peyrard-Bishop-Daxuois model by Monte Carlo simulations with no adjustable parameters. Comparison is made with previously published experimental results finding excellent agreement. Melting curves, critical DNA segment length for stability of bubbles and the possibility of a two states transition are studied.

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