Thermal Denaturation of Fluctuating DNA Driven by Bending Entropy

Details Thermal Denaturation of Fluctuating DNA Driven by Bending Entropy Thermal Denaturation of Fluctuating DNA Driven by Bending Entropy

2006-12-22

arxiv.org/abs/cond-mat/0612588v2

Physical Review Letters 99, 088103 (2007)

Physics

Condensed Matter

Soft Condensed Matter

4 pages, 1 figure

Scientific paper

10.1103/PhysRevLett.99.088103

A statistical model of homopolymer DNA, coupling internal base pair states (unbroken or broken) and external thermal chain fluctuations, is exactly solved using transfer kernel techniques. The dependence on temperature and DNA length of the fraction of denaturation bubbles and their correlation length is deduced. The thermal denaturation transition emerges naturally when the chain fluctuations are integrated out and is driven by the difference in bending (entropy dominated) free energy between broken and unbroken segments. Conformational properties of DNA, such as persistence length and mean-square-radius, are also explicitly calculated, leading, e.g., to a coherent explanation for the experimentally observed thermal viscosity transition.

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