Adhesion Induced DNA Naturation

Details Adhesion Induced DNA Naturation Adhesion Induced DNA Naturation

2005-12-12

arxiv.org/abs/cond-mat/0512237v1

Physics

Condensed Matter

Soft Condensed Matter

4 pages, 1 figure

Scientific paper

10.1103/PhysRevLett.96.098302

DNA adsorption and naturation is modeled via two interacting flexible homopolymers coupled to a solid surface. DNA denatures if the entropy gain for unbinding the two strands overcomes the loss of binding energy. When adsorbed to a surface, the entropy gain is smaller than in the bulk, leading to a stronger binding and, upon neglecting self-avoidance, absence of a denatured phase. Now consider conditions where the binding potentials are too weak for naturation, and the surface potential too weak to adsorb single strands. In a variational approach it is shown that their combined action may lead to a naturated adsorbed phase. Conditions for the absence of naturation and adsorption are derived too. The phase diagram is constructed qualitatively.

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