Dynamic disorder in receptor-ligand forced dissociation experiments

Details Dynamic disorder in receptor-ligand forced dissociation experiments Dynamic disorder in receptor-ligand forced dissociation experiments

2006-01-12

arxiv.org/abs/cond-mat/0601251v1

Physics

Condensed Matter

Statistical Mechanics

4 pages, 2 figures

Scientific paper

10.1103/PhysRevE.73.010901

Recently experiments showed that some biological noncovalent bonds increase their lifetimes when they are stretched by an external force, and their lifetimes will decrease when the force increases further. Several specific quantitative models have been proposed to explain the intriguing transitions from the "catch-bond" to the "slip-bond". Different from the previous efforts, in this work we propose that the dynamic disorder of the force-dependent dissociation rate can account for the counterintuitive behaviors of the bonds. A Gaussian stochastic rate model is used to quantitatively describe the transitions observed recently in the single bond P-selctin glycoprotein ligand 1(PSGL-1)$-$P-selectin force rupture experiment [Marshall, {\it et al.}, (2003) Nature {\bf 423}, 190-193]. Our model agrees well to the experimental data. We conclude that the catch bonds could arise from the stronger positive correlation between the height of the intrinsic energy barrier and the distance from the bound state to the barrier; classical pathway scenario or {\it a priori} catch bond assumption is not essential.

Affiliated with

Also associated with

No associations

Rating

Dynamic disorder in receptor-ligand forced dissociation experiments does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Dynamic disorder in receptor-ligand forced dissociation experiments, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dynamic disorder in receptor-ligand forced dissociation experiments will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-495580