Temperature- and Force-Induced beta-Sheet Unfolding in an Exactly Solvable Model

Details Temperature- and Force-Induced beta-Sheet Unfolding in an Exactly Solvable Model Temperature- and Force-Induced beta-Sheet Unfolding in an Exactly Solvable Model

2001-12-06

arxiv.org/abs/cond-mat/0112090v2

Physics

Condensed Matter

Soft Condensed Matter

13 pages with 4 ps figures. Revised version. A serious mistake in the original version was corrected and new simulation data w

Scientific paper

The stability of a $\beta$-sheeted conformation and its transition into a random coil are studied with a 2D lattice biopolymer model. At low temperature and low external force, the polymer folds back and forth on itself and forms a $\beta$-sheet. Our analytical calculation and Monte Carlo simulation reveal that a co-operative $\beta$-sheet--random coil transition takes places when the temperature or force is increased, with a dramatic decrease in the contact number. These predictions are in good agreement with experiments on titin protein. This transition is not a real phase-transition, indicating that backbone hydrogen-bonding alone is unable to stabilize a distinct $\beta$-sheet phase.

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