Origin of Native Driving Force in Protein Folding

Details Origin of Native Driving Force in Protein Folding Origin of Native Driving Force in Protein Folding

1999-07-27

arxiv.org/abs/cond-mat/9907432v2

Physics

Condensed Matter

LaTeX file, Postscript file; 4 pages, 1 figure (mij.eps), 2 tables

Scientific paper

10.1103/PhysRevLett.84.574

We derive an expression with four adjustable parameters that reproduces well the 20x20 Miyazawa-Jernigan potential matrix extracted from known protein structures. The numerical values of the parameters can be approximately computed from the surface tension of water, water-screened dipole interactions between residues and water and among residues, and average exposures of residues in folded proteins.

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