Protein-Mediated DNA Loops: Effects of Protein Bridge Size and Kinks

Details Protein-Mediated DNA Loops: Effects of Protein Bridge Size and Kinks Protein-Mediated DNA Loops: Effects of Protein Bridge Size and Kinks

2005-08-11

arxiv.org/abs/cond-mat/0508288v2

Physical Review E 72, 061902 (2005)

Physics

Condensed Matter

Soft Condensed Matter

corrected typos and figures, references updated; 13 pages, 7 figures, accepted for publication in Phys. Rev. E

Scientific paper

10.1103/PhysRevE.72.061902

This paper focuses on the probability that a portion of DNA closes on itself through thermal fluctuations. We investigate the dependence of this probability upon the size r of a protein bridge and/or the presence of a kink at half DNA length. The DNA is modeled by the Worm-Like Chain model, and the probability of loop formation is calculated in two ways: exact numerical evaluation of the constrained path integral and the extension of the Shimada and Yamakawa saddle point approximation. For example, we find that the looping free energy of a 100 base pairs DNA decreases from 24 kT to 13 kT when the loop is closed by a protein of r = 10 nm length. It further decreases to 5 kT when the loop has a kink of 120 degrees at half-length.

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