Probing molecular free energy landscapes by periodic loading

Details Probing molecular free energy landscapes by periodic loading Probing molecular free energy landscapes by periodic loading

2004-02-19

arxiv.org/abs/cond-mat/0402496v1

Physics

Condensed Matter

Soft Condensed Matter

4 pages, 3 figures

Scientific paper

10.1103/PhysRevLett.93.158105

Single molecule pulling experiments provide information about interactions in biomolecules that cannot be obtained by any other method. However, the reconstruction of the molecule's free energy profile from the experimental data is still a challenge, in particular for the unstable barrier regions. We propose a new method for obtaining the full profile by introducing a periodic ramp and using Jarzynski's identity for obtaining equilibrium quantities from non-equilibrium data. Our simulated experiments show that this method delivers significant more accurate data than previous methods, under the constraint of equal experimental effort.

Affiliated with

Also associated with

No associations

Rating

Probing molecular free energy landscapes by periodic loading does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Probing molecular free energy landscapes by periodic loading, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Probing molecular free energy landscapes by periodic loading will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-213908