Force Unfolding Single RNAs: from Equilibrium to Far-from Equilibrium

Details Force Unfolding Single RNAs: from Equilibrium to Far-from Equilibrium Force Unfolding Single RNAs: from Equilibrium to Far-from Equilibrium

2005-04-11

arxiv.org/abs/cond-mat/0504236v2

Physics

Condensed Matter

Soft Condensed Matter

11 pages, 9 figures

Scientific paper

We summarize the recent simulation progress of micromanipulation experiments on RNAs. Our work mainly consults with two important small RNAs unfolding experiments carried out by Bustamante group. Our results show that, in contrast to protein cases, using the single polymer elastic theory and the well known RNA secondary structure free energy knowledge, we can successively simulate various behaviors of force unfolding RNAs under different experimental setups from equilibrium to far-from equilibrium. Particularly, our simulation would be helpful in understanding Jarzynski's remarkable equality, which its experimental test has received considerable attention.

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