Resistance proof, folding-inhibitor drugs

Details Resistance proof, folding-inhibitor drugs Resistance proof, folding-inhibitor drugs

2002-10-09

arxiv.org/abs/cond-mat/0210184v1

Physics

Condensed Matter

Soft Condensed Matter

Scientific paper

10.1063/1.1545087

Conventional drugs work, as a rule, by inhibiting the enzymatic activity of specific proteins, capping their active site. In this paper we present a model of non- conventional drug design based on the inhibiting effects small peptides obtained from segments of the protein itself have on the folding ability of the system. Such peptides attach to the newly expressed (unfolded) protein and inhibit its folding, inhibition which cannot be avoided but through mutations which in any case denaturate the enzyme. These peptides, or their mimetic molecules, can be used as effective alternative drugs to those already available, displaying the advantage of not suffering from the upraise of resistence.

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