Distribution of the second virial coefficients of globular proteins

Details Distribution of the second virial coefficients of globular proteins Distribution of the second virial coefficients of globular proteins

2002-07-11

arxiv.org/abs/cond-mat/0207293v1

Europhysics Letters 60, 938-944 (2002)

Physics

Condensed Matter

Soft Condensed Matter

5 pages, including 3 figures

Scientific paper

10.1209/epl/i2002-00308-1

George and Wilson [Acta. Cryst. D 50, 361 (1994)] looked at the distribution of values of the second virial coefficient of globular proteins, under the conditions at which they crystallise. They found the values to lie within a fairly narrow range. We have defined a simple model of a generic globular protein. We then generate a set of proteins by picking values for the parameters of the model from a probability distribution. At fixed solubility, this set of proteins is found to have values of the second virial coefficient that fall within a fairly narrow range. The shape of the probability distribution of the second virial coefficient is Gaussian because the second virial coefficient is a sum of contributions from different patches on the protein surface.

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