A statistical theory of amino acid mutation

Details A statistical theory of amino acid mutation A statistical theory of amino acid mutation

Sep 1990

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1990oleb...20..419l&link_type=abstract

Origins of Life and Evolution of the Biosphere, Volume 20, Issue 5, pp.419-424

Physics

Scientific paper

Assuming that the observed mutation frequency of an amino acid depends on two factors. The first is mutation coefficient which describes the rate of the nucleotide substitution stochastically and the second is the similarity of amino acids which represents the fitness of a mutant under the selective pressure. A statistical theory is proposed and 380 mutation frequencies are calculated, only 10 of which disagree obviously with the observed data.

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