Effects of static and temporally fluctuating tensions on semiflexible polymer looping

Details Effects of static and temporally fluctuating tensions on semiflexible polymer looping Effects of static and temporally fluctuating tensions on semiflexible polymer looping

2011-12-02

arxiv.org/abs/1112.0450v1

Physics

Condensed Matter

Soft Condensed Matter

7 pages, 8 figures, accepted in the Journal of Chemical Physics

Scientific paper

10.1063/1.3673439

Biopolymer looping is a dynamic process that occurs ubiquitously in cells for gene regulation, protein folding, etc. In cellular environments, biopolymers are often subject to tensions which are either static, or temporally fluctuating far away from equilibrium. We study the dynamics of semiflexible polymer looping in the presence of such tensions by using Brownian dynamics simulation combined with an analytical theory. We show a minute tension dramatically changes the looping time, especially for long chains. Considering a dichotomically flipping noise as a simple example of the nonequilibrium tension, we find the phenomenon of resonant activation, where the looping time can be the minimum at an optimal flipping time. We discuss our results in connection with recent experiments.

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