Effects of intermediate bound states in dynamic force spectroscopy

Details Effects of intermediate bound states in dynamic force spectroscopy Effects of intermediate bound states in dynamic force spectroscopy

2003-07-10

arxiv.org/abs/cond-mat/0307251v1

Physics

Condensed Matter

Statistical Mechanics

7 pages, 5 figures

Scientific paper

10.1016/S0006-3495(04)74200-9

We revisit here some aspects of the interpretation of dynamic force spectroscopy experiments. The standard theory predicts a typical unbinding force $f^*$ linearly proportional to the logarithm of the loading rate $r$ when a single energetical barrier controls the unbinding process; for a more complex situation of $N$ barriers, it predicts at most $N$ linear segments for the $f^*$ vs. $\log(r)$ curve, each segment characterizing a different barrier. We here extend this existing picture using a refined approximation, we provide a more general analytical formula, and show that in principle up to $N(N+1)/2$ segments can show up experimentally. As a consequence the interpretation of data can be ambiguous, for the characteristics and even the number of barriers. A further possible outcome of a multiple-barrier landscape is a bimodal or multimodal distribution of the unbinding force at a given loading rate, a feature recently observed experimentally.

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