Preferential attachment in the protein network evolution

Details Preferential attachment in the protein network evolution Preferential attachment in the protein network evolution

2003-03-23

arxiv.org/abs/cond-mat/0303490v2

Phys. Rev. Lett. 91, 138701 (2003) .

Physics

Condensed Matter

Statistical Mechanics

Minor changes per referees requests; to appear in PRL

Scientific paper

10.1103/PhysRevLett.91.138701

The Saccharomyces cerevisiae protein-protein interaction map, as well as many natural and man-made networks, shares the scale-free topology. The preferential attachment model was suggested as a generic network evolution model that yields this universal topology. However, it is not clear that the model assumptions hold for the protein interaction network. Using a cross genome comparison we show that (a) the older a protein, the better connected it is, and (b) The number of interactions a protein gains during its evolution is proportional to its connectivity. Therefore, preferential attachment governs the protein network evolution. The evolutionary mechanism leading to such preference and some implications are discussed.

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