Vibrational properties of inclusion complexes: the case of indomethacin-cyclodextrin

Details Vibrational properties of inclusion complexes: the case of indomethacin-cyclodextrin Vibrational properties of inclusion complexes: the case of indomethacin-cyclodextrin

2006-05-11

arxiv.org/abs/cond-mat/0605303v1

Physics

Condensed Matter

Soft Condensed Matter

14 file figures

Scientific paper

10.1063/1.2217952

Vibrational properties of inclusion complexes with cyclodextrins are studied by means of Raman spectroscopy and numerical simulation. In particular, Raman spectra of the non-steroidal, anti-inflammatory drug indomethacin undergo notable changes in the energy range between 1600 and 1700 cm$^{-1}$ when inclusion complexes with cyclodextrins are formed. By using both \emph{ab initio} quantum chemical calculations and molecular dynamics, we studied how to relate such changes to the geometry of the inclusion process, disentangling single-molecule effects, from changes in the solid state structure or dimerization processes.

Affiliated with

Also associated with

No associations

Rating

Vibrational properties of inclusion complexes: the case of indomethacin-cyclodextrin does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Vibrational properties of inclusion complexes: the case of indomethacin-cyclodextrin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vibrational properties of inclusion complexes: the case of indomethacin-cyclodextrin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-469384