Unifying thermodynamic and kinetic descriptions of single-molecule processes: RNA unfolding under tension

Details Unifying thermodynamic and kinetic descriptions of single-molecule processes: RNA unfolding under tension Unifying thermodynamic and kinetic descriptions of single-molecule processes: RNA unfolding under tension

2007-09-17

arxiv.org/abs/0709.2609v1

J. Phys. Chem. B, 111 (32), 9598 -9602, 2007

Physics

Condensed Matter

Statistical Mechanics

13 pages, 3 figures

Scientific paper

10.1021/jp073413w

We use mesoscopic non-equilibrium thermodynamics theory to describe RNA unfolding under tension. The theory introduces reaction coordinates, characterizing a continuum of states for each bond in the molecule. The unfolding considered is so slow that one can assume local equilibrium in the space of the reaction coordinates. In the quasi-stationary limit of high sequential barriers, our theory yields the master equation of a recently proposed sequential-step model. Non-linear switching kinetics is found between open and closed states. Our theory unifies the thermodynamic and kinetic descriptions and offers a systematic procedure to characterize the dynamics of the unfolding process

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