Unfolding and unzipping of single-stranded DNA by stretching

Details Unfolding and unzipping of single-stranded DNA by stretching Unfolding and unzipping of single-stranded DNA by stretching

2003-04-10

arxiv.org/abs/cond-mat/0304250v2

Physics

Condensed Matter

Soft Condensed Matter

7 pages, 4 figures, substantially revised version

Scientific paper

10.1103/PhysRevE.70.051901

We present a theoretical study of single-stranded DNA under stretching. Within the proposed framework, the effects of basepairing on the mechanical response of the molecule can be studied in combination with an arbitrary underlying model of chain elasticity. In a generic case, we show that the stretching curve of ssDNA exhibits two distinct features: the second-order "unfolding" phase transition, and a sharp crossover, reminiscent of the first-order "unzipping" transition in dsDNA. We apply the theory to the particular cases of Worm-like Chain (WLC) and Freely-Joint Chain (FJC) models, and discuss the universal and model--dependent features of the mechanical response of ssDNA. In particular, we show that variation of the width of the unzipping crossover with interaction strength is very sensitive to the energetics of hairpin loops. This opens a new way of testing the elastic properties of ssDNA.

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