Understanding surface-adsorption of proteins: the Vroman effect

Details Understanding surface-adsorption of proteins: the Vroman effect Understanding surface-adsorption of proteins: the Vroman effect

2012-02-16

arxiv.org/abs/1202.3796v1

Physics

Condensed Matter

Soft Condensed Matter

Scientific paper

It is now well accepted that cellular responses to materials in a biological medium reflect greatly the adsorbed biomolecular layer, rather than the material itself. Here, we study by molecular dynamic simulations the competitive protein adsorption on a surface (Vroman-like effect), i.e. the non-monotonic behavior of the amount of protein adsorbed on a surface in contact with plasma as a function of contact time and plasma concentration. We show how the effect can be understood, controlled and inverted.

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