TYPE II DNA: when the interfacial energy becomes negative

Details TYPE II DNA: when the interfacial energy becomes negative TYPE II DNA: when the interfacial energy becomes negative

2010-09-06

arxiv.org/abs/1009.1021v3

Europhysics Letters 95 (2011) 48009

Physics

Condensed Matter

Statistical Mechanics

4 pages, 2 figures, Abstract and Text modified in 3rd version

Scientific paper

An important step in transcription of a DNA base sequence to a protein is the initiation from the exact starting point, called promoter region. We propose a physical mechanism for identification of the promoter region, which relies on a new classification of DNAs into two types, Type-I and Type-II, like superconductors, depending on the sign of the energy of the interface separating the zipped and the unzipped phases. This is determined by the energies of helical ordering and stretching over two independent length scales. The negative interfacial energy in Type II DNA leads to domains of helically ordered state separated by defect regions, or blobs, enclosed by the interfaces. The defect blobs, pinned by non-coding promoter regions, would be physically distinct from all other types of bubbles. We also show that the order of the melting transition under a force is different for Type I and Type II.

Affiliated with

Also associated with

No associations

Rating

TYPE II DNA: when the interfacial energy becomes negative does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with TYPE II DNA: when the interfacial energy becomes negative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and TYPE II DNA: when the interfacial energy becomes negative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-297923