Thermoresponsive micropatterned substrates for single cell studies

Details Thermoresponsive micropatterned substrates for single cell studies Thermoresponsive micropatterned substrates for single cell studies

2011-11-10

arxiv.org/abs/1111.2510v1

Physics

Condensed Matter

Soft Condensed Matter

Scientific paper

We describe the design of micropatterned surfaces for single cell studies, based on thermoresponsive polymer brushes. We show that brushes made of poly(N-isopropylacrylamide) grafted at high surface density display excellent protein and cell anti-adhesive properties. Such brushes are readily patterned at the micron scale via deep UV photolithography. A proper choice of the adhesive pattern shapes, combined with the temperature-dependent swelling properties of PNIPAM, allow us to use the polymer brush as a microactuator which induces cell detachment when the temperature is reduced below 32degC.

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