Theoretical models for single-molecule DNA and RNA experiments: from elasticity to unzipping

Details Theoretical models for single-molecule DNA and RNA experiments: from elasticity to unzipping Theoretical models for single-molecule DNA and RNA experiments: from elasticity to unzipping

2002-06-13

arxiv.org/abs/cond-mat/0206238v1

Physics

Condensed Matter

Soft Condensed Matter

to appear in CRAS, special issue dedicated to Single Molecule Experiments

Scientific paper

We review statistical-mechanical theories of single-molecule micromanipulation experiments on nucleic acids. First, models for describing polymer elasticity are introduced. We then review how these models are used to interpret single-molecule force-extension experiments on single-stranded and double-stranded DNA. Depending on the force and the molecules used, both smooth elastic behaviors and abrupt structural transitions are observed. Third, we show how combining the elasticity of two single nucleic acid strands with a description of the base-pairing interactions between them explains much of the phenomenology and kinetics of RNA and DNA `unzipping' experiments.

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