The thermal denaturation of DNA studied with neutron scattering

Physics – Condensed Matter – Statistical Mechanics

Scientific paper

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accepted for publication in Physical Review Letters

Scientific paper

10.1103/PhysRevLett.106.048101

The melting transition of deoxyribonucleic acid (DNA), whereby the strands of the double helix structure completely separate at a certain temperature, has been characterized using neutron scattering. A Bragg peak from B-form fibre DNA has been measured as a function of temperature, and its widths and integrated intensities have been interpreted using the Peyrard-Bishop-Dauxois (PBD) model with only one free parameter. The experiment is unique, as it gives spatial correlation along the molecule through the melting transition where other techniques cannot.

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