The self-assembly and evolution of homomeric protein complexes

Details The self-assembly and evolution of homomeric protein complexes The self-assembly and evolution of homomeric protein complexes

2008-11-22

arxiv.org/abs/0811.3716v1

Phys. Rev. Lett. 102, 118106 (2009)

Biology

Quantitative Biology

Biomolecules

4 pages, 4 figures

Scientific paper

10.1103/PhysRevLett.102.118106

We introduce a simple "patchy particle" model to study the thermodynamics and dynamics of self-assembly of homomeric protein complexes. Our calculations allow us to rationalize recent results for dihedral complexes. Namely, why evolution of such complexes naturally takes the system into a region of interaction space where (i) the evolutionarily newer interactions are weaker, (ii) subcomplexes involving the stronger interactions are observed to be thermodynamically stable on destabilization of the protein-protein interactions and (iii) the self-assembly dynamics are hierarchical with these same subcomplexes acting as kinetic intermediates.

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