The role of the coating and aggregation state in the interactions between iron oxide nanoparticles and 3T3 fibroblasts

Details The role of the coating and aggregation state in the interactions between iron oxide nanoparticles and 3T3 fibroblasts The role of the coating and aggregation state in the interactions between iron oxide nanoparticles and 3T3 fibroblasts

2011-08-10

arxiv.org/abs/1108.2395v1

Physics Procedia 9 (2010) 266--269

Physics

Condensed Matter

Materials Science

5 pages 3 figures

Scientific paper

10.1016/j.phpro.2010.11.059

Recent nanotoxicity studies revealed that the physico-chemical characteristics of engineered nanomaterials play an important role in the interactions with living cells. Here, we report on the toxicity and uptake of the iron oxide sub-10 nm nanoparticles by NIH/3T3 mouse fibroblasts. Coating strategies include low-molecular weight ligands (citric acid) and polymers (poly(acrylic acid), MW = 2000 g mol-1). We find that most particles were biocompatible, as exposed cells remained 100% viable relative to controls. The strong uptake shown by the citrate-coated particles is related to the destabilization of the dispersions in the cell culture medium and their sedimentation down to the cell membranes.

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