Physics – Condensed Matter – Statistical Mechanics
Scientific paper
2011-03-16
Physics
Condensed Matter
Statistical Mechanics
26 pages, 8 figures
Scientific paper
A simple stochastic model which describes microtubule dynamics and explicitly takes into account the relevant biochemical processes is presented. The model incorporates binding and unbinding of monomers and random phosphate release inside the polymer. It is shown that this theoretical approach provides a microscopic picture of the dynamic instability phenomena of microtubules. The cap size, the concentration dependence of the catastrophe times and the delay before observing catastrophes following a dilution can be quantitatively predicted by this approach in a direct and simple way. Furthermore, the model can be solved analytically to a large extend, thus offering a valuable starting point for more refined studies of microtubules dynamics.
Kolomeisky Anatoly B.
Lacoste David
Padinhateeri Ranjith
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