The protons of space and brain tumors II. Cellular and molecular considerations

Details The protons of space and brain tumors II. Cellular and molecular considerations The protons of space and brain tumors II. Cellular and molecular considerations

May 1989

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1989aipc..186..412n&link_type=abstract

HIGH-ENERGY RADIATION BACKGROUND IN SPACE. AIP Conference Proceedings, Volume 186, pp. 412-431 (1989).

Physics

Medical Physics

Aerospace Bio- And Medical Physics

Scientific paper

An increased incidence of highly malignant gliomas, termed glioblastoma multiforme has been observed in Rhesus monkeys irradiated with 55 MeV protons, and in humans treated with therapeutic irradiation to the head. The results suggest a radiation etiology for these tumors. In this paper, we review briefly some characteristics of glioma tumors, and summarize the genetic changes associated with malignant gliomas in experimental animals and in humans. The genetic abnormalities include cytogenetic alterations, and changes in the structure and expression of specific oncogenes. We discuss the potential for these genetic changes to contribute to several putative mechanism leading to aberrant growth stimulation and, ultimately, to tumorigenesis. In addition, we review briefly some recent data concerning the molecular nature of radiation-induced somatic cell mutation and oncogene activation, and discuss the significance of these results for the radiation etiology of malignant gliomas. Finally, some implications of these results are discussed in relation to human radiation exposure in space.

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