The Lack of Long Range Correlations is a Necessary Condition for a Functional Biologically Active Protein

Details The Lack of Long Range Correlations is a Necessary Condition for a Functional Biologically Active Protein The Lack of Long Range Correlations is a Necessary Condition for a Functional Biologically Active Protein

1998-02-20

arxiv.org/abs/cond-mat/9802225v3

J.Phys. A 1997, v.30, N 22, 7765-73

Physics

Condensed Matter

Soft Condensed Matter

14 pages, 5 figures

Scientific paper

We study random heteropolymer chain with gaussian distribution of kinds of monomers. The long-range correlations between kinds of monomers were introduce. The mean-field analysis of such heteropolymer indicates the existence of infinite energetic barrier between heteropolymer random coil and frozen states. Thus, the frozen state is kinetically unavailable for the random heteropolymer with power-law correlations in monomers' sequence. The relationship between our results and some early obtained results for the DNA intrones sequences are discussed.

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