Physics – Condensed Matter – Soft Condensed Matter
Scientific paper
2007-05-15
Physics
Condensed Matter
Soft Condensed Matter
Scientific paper
10.1529/biophysj.107.113902
We present a model improving the two-angle model for interphase chromatin (E2A model). This model takes into account the cylindrical shape of the histone octamers, the H1 histones in front of the nucleosomes and the vertical distance $d$ between the in and outgoing DNA strands. Factoring these chromatin features in, one gets essential changes in the chromatin phase diagram: Not only the shape of the excluded-volume borderline changes but also the vertical distance $d$ has a dramatic influence on the forbidden area. Furthermore, we examined the influence of H1 defects on the properties of the chromatin fiber. Thus we present two possible strategies for chromatin compaction: The use of very dense states in the phase diagram in the gaps in the excluded volume borderline or missing H1 histones which can lead to very compact fibers. The chromatin fiber might use both of these mechanisms to compact itself at least locally. Line densities computed within the model coincident with the experimental values.
Diesinger Philipp M.
Heermann Dieter W.
No associations
LandOfFree
The influence of the cylindrical shape of the nucleosomes and H1 defects on properties of chromatin does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with The influence of the cylindrical shape of the nucleosomes and H1 defects on properties of chromatin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and The influence of the cylindrical shape of the nucleosomes and H1 defects on properties of chromatin will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-623381