Physics – Condensed Matter – Soft Condensed Matter
Scientific paper
2002-09-13
Journal of Chemical Physics v118, p5157-5161 (2003)
Physics
Condensed Matter
Soft Condensed Matter
7 pages, 3 figures. v2 has new brief discussion of charge effects on protein interactions in vivo
Scientific paper
10.1063/1.1544556
Bacteria typically have a few thousand different proteins. The number of proteins with a given charge is a roughly Gaussian function of charge - centred near zero, and with a width around ten (in units of the charge on the proton). We have used the charges on E. coli's proteins to estimate the changes in the second virial coefficients of all its proteins as the concentration of a 1:1 salt is increased. The second virial coefficient has dimensions of volume and we find that on average it decreases by about twice the average volume of a protein when the salt concentration is increased from 0.2 to 1 Molar. The standard deviation of the decrease is of the same order. The consequences of this for the complex mixture of proteins inside an E. coli cell, are briefly discussed.
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