The effect of topology on the structure and free energy landscape of DNA kissing complexes

Details The effect of topology on the structure and free energy landscape of DNA kissing complexes The effect of topology on the structure and free energy landscape of DNA kissing complexes

2012-03-15

arxiv.org/abs/1203.3577v1

Physics

Condensed Matter

Soft Condensed Matter

Scientific paper

We use a recently developed coarse-grained model for DNA to study kissing complexes formed by hybridization of complementary hairpin loops. The binding of the loops is topologically constrained because their linking number must remain constant. By studying systems with linking numbers -1, 0 or 1 we show that the average number of interstrand base pairs is larger when the topology is more favourable for the right-handed wrapping of strands around each other. The thermodynamic stability of the kissing complex also decreases when the linking number changes from -1 to 0 to 1. The structures of the kissing complexes typically involve two intermolecular helices that coaxially stack with the hairpin stems at a parallel four-way junction.

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