Physics – Condensed Matter – Soft Condensed Matter
Scientific paper
2001-09-20
Biophys. J. 81, 3146-3155 (2001)
Physics
Condensed Matter
Soft Condensed Matter
REVTeX, 10 pages, 9 figures; to appear in Biophysical Journal; minor corrections
Scientific paper
10.1016/S0006-3495(01)75951-6
We discuss a theoretical model for the cooperative binding dynamics of tropomyosin to actin filaments. Tropomyosin binds to actin by occupying seven consecutive monomers. The model includes a strong attraction between attached tropomyosin molecules. We start with an empty lattice and show that the binding goes through several stages. The first stage represents fast initial binding and leaves many small vacancies between blocks of bound molecules. In the second stage the vacancies annihilate slowly as tropomyosin molecules detach and re-attach. Finally the system approaches equilibrium. Using a grain-growth model and a diffusion-coagulation model we give analytical approximations for the vacancy density in all regimes.
No associations
LandOfFree
The binding dynamics of tropomyosin on actin does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with The binding dynamics of tropomyosin on actin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and The binding dynamics of tropomyosin on actin will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-657345