Testing the transition state theory in stochastic dynamics of a genetic switch

Details Testing the transition state theory in stochastic dynamics of a genetic switch Testing the transition state theory in stochastic dynamics of a genetic switch

2006-08-25

arxiv.org/abs/cond-mat/0608548v1

Physics

Condensed Matter

Disordered Systems and Neural Networks

Scientific paper

10.1016/j.cplett.2006.08.114

Stochastic dynamics of chemical reactions in a mutually repressing two-gene circuit is numerically simulated. The circuit has a rich variety of different states when the kinetic change of DNA status is slow. The stochastic switching transition between those states are compared with the theoretical estimation of the switching rate derived from the idea similar to the transition state theory. Even though the circuit is kept far from equilibrium, the method gives a consistent explanation of the switching kinetics for a wide range of parameters. The transition state theory-like estimation, however, fails to describe transitions involving the state which has the extremely small numbers of protein molecules.

Affiliated with

Also associated with

No associations

Rating

Testing the transition state theory in stochastic dynamics of a genetic switch does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Testing the transition state theory in stochastic dynamics of a genetic switch, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Testing the transition state theory in stochastic dynamics of a genetic switch will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-111249