Test of cold denaturation mechanism for proteins as a function of water's structure

Details Test of cold denaturation mechanism for proteins as a function of water's structure Test of cold denaturation mechanism for proteins as a function of water's structure

2006-03-09

arxiv.org/abs/cond-mat/0603240v1

Physics

Condensed Matter

Other Condensed Matter

5 pages, 5 figures

Scientific paper

10.1016/j.physa.2006.08.077

In a recent paper [PRL 91, 138103 (2003)] a new mechanism to explain the cold denaturation of proteins, based on the loss of local low-density water structure, has been proposed. In the present paper this mechanism is tested by means of full atom numerical simulations. In good agreement with this proposal, cold denaturation resulting in the unfolded state was found at the High Density Liquid (HDL) state of water, at which the amount of open tetragonal hydrogen bonds decreases at cooling.

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