Temperature dependence of normal mode reconstructions of protein dynamics

Details Temperature dependence of normal mode reconstructions of protein dynamics Temperature dependence of normal mode reconstructions of protein dynamics

2008-10-27

arxiv.org/abs/0810.4771v1

Physics

Condensed Matter

Statistical Mechanics

Scientific paper

Normal mode analysis is a widely used technique for reconstructing conformational changes of proteins from the knowledge of native structures. In this Letter, we investigate to what extent normal modes capture the salient features of the dynamics over a range of temperatures from close to T = 0 to above unfolding. We show that on the one hand, the use of normal modes at physiological temperatures is justified provided proteins are cooperative. On the other hand, it is imperative to consider several modes in order to eliminate the unpredictable temperature dependence of single- mode contributions to the protein fluctuations.

Affiliated with

Also associated with

No associations

Rating

Temperature dependence of normal mode reconstructions of protein dynamics does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Temperature dependence of normal mode reconstructions of protein dynamics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Temperature dependence of normal mode reconstructions of protein dynamics will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-323753