Structurally specific thermal fluctuations identify functional sites for DNA transcription

Details Structurally specific thermal fluctuations identify functional sites for DNA transcription Structurally specific thermal fluctuations identify functional sites for DNA transcription

2003-09-05

arxiv.org/abs/cond-mat/0309157v2

EUROPHYSICS LETTERS 68, 127-133 (2004)

Physics

Condensed Matter

Soft Condensed Matter

Scientific paper

10.1209/epl/i2004-10167-8

We report results showing that thermally-induced openings of double stranded DNA coincide with the location of functionally relevant sites for transcription. Investigating both viral and bacterial DNA gene promoter segments, we found that the most probable opening occurs at the transcription start site. Minor openings appear to be related to other regulatory sites. Our results suggest that coherent thermal fluctuations play an important role in the initiation of transcription. Essential elements of the dynamics, in addition to sequence specificity, are nonlinearity and entropy, provided by local base-pair constraints.

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