Stretching of a single-stranded DNA: Evidence for structural transition

Details Stretching of a single-stranded DNA: Evidence for structural transition Stretching of a single-stranded DNA: Evidence for structural transition

2009-07-11

arxiv.org/abs/0907.1950v1

Phys. Rev. E 79, 031930 (2009)

Physics

Condensed Matter

Soft Condensed Matter

10 pages, 4 figures

Scientific paper

Recent experiments have shown that the force-extension (F-x) curve for single-stranded DNA (ssDNA) consisting only of adenine [poly(dA)] is significantly different from thymine [poly(dT)]. Here, we show that the base stacking interaction is not sufficient to describe the F-x curves as seen in the experiments. A reduction in the reaction co-ordinate arising from the formation of helix at low forces and an increase in the distance between consecutive phosphates of unstacked bases in the stretched state at high force in the proposed model, qualitatively reproduces the experimentally observed features. The multi-step plateau in the F-x curve is a signature of structural change in ssDNA.

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