Stochastic model for nucleosome sliding in the presence of DNA ligands

Details Stochastic model for nucleosome sliding in the presence of DNA ligands Stochastic model for nucleosome sliding in the presence of DNA ligands

2008-07-20

arxiv.org/abs/0807.3150v1

Phys. Rev. E, 79, 031922 (2009)

Physics

Condensed Matter

Soft Condensed Matter

10 pages, 8 figures, submitted to Eur. Phys. J. E

Scientific paper

Heat-induced mobility of nucleosomes along DNA is an experimentally well-studied phenomenon. A recent experiment shows that the repositioning is modified in the presence of minor-groove binding DNA ligands. We present here a stochastic three-state model for the diffusion of a nucleosome along DNA in the presence of such ligands. It allows us to describe the dynamics and the steady state of such a motion analytically. The analytical results are in excellent agreement with numerical simulations of this stochastic process.With this model, we study the response of a nucleosome to an external force and how it is affected by the presence of ligands.

Affiliated with

Also associated with

No associations

Rating

Stochastic model for nucleosome sliding in the presence of DNA ligands does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Stochastic model for nucleosome sliding in the presence of DNA ligands, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stochastic model for nucleosome sliding in the presence of DNA ligands will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-419976