Speeding up a single-molecule DNA motor with a simple catalyst

Details Speeding up a single-molecule DNA motor with a simple catalyst Speeding up a single-molecule DNA motor with a simple catalyst

2004-12-10

arxiv.org/abs/cond-mat/0412287v2

Phys. Rev. E 72, 051918 (2005)

Physics

Condensed Matter

Soft Condensed Matter

6 pages, 5 figures New figure (Fig. 6) and appendix added. Text revised

Scientific paper

10.1103/PhysRevE.72.051918

We demonstrate a catalytic control method for speeding up the single-molecule DNA motor introduced by Li and Tan [Nano Lett. {\bf 2}, 315 (2002)]. A key rate-limiting barrier in the reaction part of the cycle is the tendency for the second fuel strand $B$ to fold into the chair-like configuration of the original motor strand $M$. This seriously impedes the restoration reaction. We have designed a catalytic strand to inhibit the folding of $B$. Introduction of the catalyst speeds up the restoration reaction by roughly a factor of 2. The catalyst shows robust behavior for more than one cycle. The experimental data can be understood with a model with intermediate products. This technique provides dynamic control of the restoration rate of the motor without affecting the straightening rate.

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